Strength and audience?

Is an article in a medical journal not a good one if I don’t happen to understand the concepts behind it? Was Galileo wrong, because the Roman Catholic church didn’t know or accept the premise he was working on? No, those are false statements. It is strong in the concept of the image in conveyed. If you do not know the concept and are unable to interpret it you are either not paying enough attention to the image or you are not in the intended audience of the artist and are therefore excluded from the work.
Duchamp works with many influences in his creative process. The fact that he uses word plays and jokes in his visual formation creates a small set of optimal viewers in his audience. This works against the ability to have a universal of the work. This allows for the viewer to create a more personal story on the basis of the title and the abstract imagery.
On the other hand, Janine Antoni works with a process and materials that are familiar to everyone and leads to the concept in a not to obtuse manner. If the show does not mention how the secondary products have been produces or what they were specifically produced from the earlier objects, then becomes the obscuring of the lines of the strong piece, but that might become an issue with presentation.
The question to me is the size of the audience that the artist is looking for. What is too general and what is too specific for the viewer so that they have interest in the piece and they are still able to relate to it.